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        what causes insulin resistance? 
  
  
    
       
       No one knows for sure. Some scientists think a defect in specific genes may cause insulin resistance and type 2 diabetes. Researchers continue to investigate the cause. 
      What we do know is that insulin resistance is aggravated by obesity and physical inactivity both of which are increasing in the U.S. 
       
        
       
        
          
          
          
        
        
          
            
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